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Gene Ontology Classifications
Symbol
Name
ID
Efnb1
ephrin B1
MGI:102708

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GO curators for mouse genes have assigned the following annotations to the gene product of Efnb1. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Bruckner K et al. (1999) EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron, 22:511-24. (PubMed:10197531)
  2. Davy A et al. (2004) Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev, 18:572-83. (PubMed:15037550)
  3. Georgakopoulos A et al. (2006) Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. EMBO J, 25:1242-52. (PubMed:16511561)
  4. Imondi R et al. (2001) Commissural axon pathfinding on the contralateral side of the floor plate: a role for B-class ephrins in specifying the dorsoventral position of longitudinally projecting commissural axons. Development, 128:4859-71. (PubMed:11731465)
  5. Lin D et al. (1999) The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. J Biol Chem, 274:3726-33. (PubMed:9920925)
  6. Tanaka M et al. (2004) Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2. EMBO J, 23:1075-88. (PubMed:14988728)
  7. Wu C et al. (2009) ZHX2 Interacts with Ephrin-B and regulates neural progenitor maintenance in the developing cerebral cortex. J Neurosci, 29:7404-12. (PubMed:19515908)
  8. Yu G et al. (2004) EphrinB1 is essential in T-cell-T-cell co-operation during T-cell activation. J Biol Chem, 279:55531-9. (PubMed:15502157)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory