Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Efnb1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Efnb1
  • participates in the following biological processes:
    • positive regulation of T cell proliferation ^[6]
  • is located in the following cellular components:
    • cytoplasm ^[5]
    • membrane raft ^[1]
    • nucleus ^[5]
• The gene product of Efnb1 has been shown to bind to the gene products of Efna2, Zhx2. ^{[4, 5]} Researchers have inferred, based on physical interactions, that the gene product of Efnb1
  • performs the following molecular functions:
    • ephrin receptor binding ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Efnb1
  • participates in the following biological processes:
    • axon guidance ^[3]
    • embryonic pattern specification ^[2]
    • neural crest cell migration ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Efnb1:
  • participates in the following biological processes:
    • nervous system development
  • is located in the following cellular components:
    • synapse

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Summary text based on GO annotations supported by structural data

• Efnb1 encodes a protein or proteins that contain the following InterPro domains: Cupredoxin, Ephrin, Ephrin, conserved site, indicating that the gene product:
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Efnb1 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Bruckner K et al. (1999) EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron, 22:511-24. (PubMed:10197531)
2. Davy A et al. (2004) Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev, 18:572-83. (PubMed:15037550)
3. Imondi R et al. (2001) Commissural axon pathfinding on the contralateral side of the floor plate: a role for B-class ephrins in specifying the dorsoventral position of longitudinally projecting commissural axons. Development, 128:4859-71. (PubMed:11731465)
4. Tanaka M et al. (2004) Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2. EMBO J, 23:1075-88. (PubMed:14988728)
5. Wu C et al. (2009) ZHX2 Interacts with Ephrin-B and regulates neural progenitor maintenance in the developing cerebral cortex. J Neurosci, 29:7404-12. (PubMed:19515908)
6. Yu G et al. (2004) EphrinB1 is essential in T-cell-T-cell co-operation during T-cell activation. J Biol Chem, 279:55531-9. (PubMed:15502157)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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