Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Abcc1. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid hormones and their metabolites. [provided by RefSeq, Nov 2011]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Abcc1
  • is located in the following cellular components:
    • integral to plasma membrane ^[1]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Abcc1:
  • participates in the following biological processes:
    • ATP catabolic process
    • cell chemotaxis
    • daunorubicin transport
    • drug export
    • drug transmembrane transport
    • glutathione transmembrane transport
    • negative regulation of neuron death
    • phospholipid efflux
    • plasma membrane long-chain fatty acid transport
    • positive regulation of cell migration
    • response to drug
    • response to oxidative stress
    • transmembrane transport
    • xenobiotic transport
  • performs the following molecular functions:
    • ATPase activity
    • drug transmembrane transporter activity
    • efflux transmembrane transporter activity
    • glutathione S-conjugate-exporting ATPase activity
    • glutathione transmembrane transporter activity
    • lipid-transporting ATPase activity
    • long-chain fatty acid transporter activity
    • sphingolipid transporter activity
    • xenobiotic-transporting ATPase activity
  • is located in the following cellular components:
    • basolateral plasma membrane
    • cytoplasm
    • Golgi apparatus
    • integral to plasma membrane
    • membrane
    • nucleus
    • plasma membrane

---

Summary text based on GO annotations supported by structural data

• Abcc1 encodes a protein or proteins that contain the following InterPro domains: AAA+ ATPase domain, ABC transporter, conserved site, ABC transporter, integral membrane type 1, ABC transporter, transmembrane domain, ABC transporter, transmembrane domain, type 1, ABC transporter-like, Multi drug resistance-associated protein, indicating that the gene product:
  • participates in the following biological processes:
    • ATP catabolic process
    • metabolic process
    • transmembrane transport
    • transport
  • performs the following molecular functions:
    • ATP binding
    • ATPase activity, coupled to transmembrane movement of substances
    • nucleoside-triphosphatase activity
    • nucleotide binding
    • transporter activity
  • is located in the following cellular components:
    • integral to membrane

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Abcc1 indicates that it:
  • participates in the following biological processes:
    • metabolic process
    • transport
  • performs the following molecular functions:
    • ATP binding
    • hydrolase activity
    • nucleotide binding
  • is located in the following cellular components:
    • integral to membrane

---

References

1. Tanaka Y et al. (2003) Expressions of hepatobiliary organic anion transporters and bilirubin-conjugating enzyme in differentiating embryonic stem cells. Biochem Biophys Res Commun, 309:324-30. (PubMed:12951053)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---