Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ppp5c. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to hormones or cellular stress, and elevated levels of this protein may be associated with breast cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ppp5c
  • is located in the following cellular components:
    • cytosol ^[2]
• The gene product of Ppp5c has been shown to bind to the gene products of Nr3c1. ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ppp5c
  • participates in the following biological processes:
    • dephosphorylation ^[1]
    • response to morphine ^[1]
  • performs the following molecular functions:
    • phosphoprotein phosphatase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ppp5c:
  • participates in the following biological processes:
    • positive regulation of I-kappaB kinase/NF-kappaB cascade
    • protein heterooligomerization
    • signal transduction
  • performs the following molecular functions:
    • identical protein binding
    • phosphoprotein phosphatase activity
    • signal transducer activity
  • is located in the following cellular components:
    • cytoplasm
    • Golgi apparatus
    • neuron projection
    • neuronal cell body
    • nucleus

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Summary text based on GO annotations supported by structural data

• Ppp5c encodes a protein or proteins that contain the following InterPro domains: Metallophosphoesterase domain, PPP domain, Serine/threonine protein phosphatase 5, Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase, Tetratricopeptide repeat, Tetratricopeptide repeat-containing domain, Tetratricopeptide TPR-1, Tetratricopeptide-like helical, indicating that the gene product:
  • participates in the following biological processes:
    • protein dephosphorylation
  • performs the following molecular functions:
    • hydrolase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ppp5c indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding

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References

1. Maeda T et al. (2005) Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP2A and PP5 estimated by tail-pinch test in mice. Brain Res, 1056:191-9. (PubMed:16102737)
2. Yoshinari K et al. (2003) Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital. FEBS Lett, 548:17-20. (PubMed:12885400)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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