Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits RNA polymerase II activating transcription factor binding activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II transcription factor binding activity. Involved in several processes, including negative regulation of neuron differentiation; regulation of transcription, DNA-templated; and signal transduction involved in regulation of gene expression. Localizes to nuclear chromatin. Is expressed in several structures, including 4-cell stage embryo; embryo mesenchyme; embryo mesoderm; genitourinary system; and primitive streak. Used to study spondylocostal dysostosis. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human TBX6 (T-box transcription factor 6).