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Gene Ontology Classifications
Symbol
Name
ID
Pou4f2
POU domain, class 4, transcription factor 2
MGI:102524

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pou4f2. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the POU-domain transcription factor family and may be involved in maintaining visual system neurons in the retina. The level of the encoded protein is also elevated in a majority of breast cancers, resulting in accelerated tumor growth. [provided by RefSeq, Sep 2011]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Dawson SJ et al. (1996) The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements. Biochem J, 314:439-43. (PubMed:8670054)
  2. Erkman L et al. (2000) A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system. Neuron, 28:779-92. (PubMed:11163266)
  3. Erkman L et al. (1996) Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature, 381:603-6. (PubMed:8637595)
  4. Farooqui-Kabir SR et al. (2008) Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression. Cell Stress Chaperones, 13:297-312. (PubMed:18368538)
  5. Gan L et al. (1999) POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification. Dev Biol, 210:469-80. (PubMed:10357904)
  6. Jin K et al. (2010) Early B-cell factors are required for specifying multiple retinal cell types and subtypes from postmitotic precursors. J Neurosci, 30:11902-16. (PubMed:20826655)
  7. Pan L et al. (2008) ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells. Development, 135:1981-90. (PubMed:18434421)
  8. Qiu F et al. (2008) A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors. J Neurosci, 28:3392-403. (PubMed:18367606)
  9. Rocha SF et al. (2009) Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity. Dev Biol, 328:54-65. (PubMed:19389377)
  10. Wagner KD et al. (2003) The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b). Gene, 305:217-23. (PubMed:12609742)
  11. Wang SW et al. (2002) Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development, 129:467-77. (PubMed:11807038)
  12. Xiang M. (1998) Requirement for Brn-3b in early differentiation of postmitotic retinal ganglion cell precursors. Dev Biol, 197:155-69. (PubMed:9630743)
  13. Xiang M et al. (1998) Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells. Development, 125:3935-46. (PubMed:9735355)
  14. Xiang M et al. (1995) The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons. J Neurosci, 15:4762-85. (PubMed:7623109)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory