Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and mitogen-activated protein kinase p38 binding activity. Involved in heart development and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including circulatory system development; leukocyte differentiation; and negative regulation of cell population proliferation. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including eye; genitourinary system; heart; hemolymphoid system; and limb mesenchyme. Human ortholog(s) of this gene implicated in congenital heart disease and ventricular septal defect. Orthologous to human NFATC1 (nuclear factor of activated T cells 1).