Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits DNA-binding transcription factor activity; transcription factor binding activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including anoikis; lens fiber cell apoptotic process; and negative regulation of fat cell differentiation. Localizes to cytoplasm; nuclear chromatin; and transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and retina. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; lung small cell carcinoma; lung squamous cell carcinoma; pancreatic adenocarcinoma; and pancreatic ductal adenocarcinoma. Orthologous to human E2F1 (E2F transcription factor 1).