Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in DNA-templated transcription; negative regulation of fat cell differentiation; and negative regulation of fat cell proliferation. Acts upstream of or within several processes, including anoikis; intrinsic apoptotic signaling pathway by p53 class mediator; and lens fiber cell apoptotic process. Located in cytoplasm and nucleus. Part of chromatin and transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and lung. Used to study Sjogren's syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in lung carcinoma (multiple); osteosarcoma; and pancreatic adenocarcinoma (multiple). Orthologous to human E2F1 (E2F transcription factor 1).
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