Automated description from the Alliance of Genome Resources
Exhibits chromatin binding activity and guanine/thymine mispair binding activity. Predicted to contribute to MutSalpha complex binding activity and single-stranded DNA binding activity. Involved in several processes, including meiotic nuclear division; nucleic acid metabolic process; and regulation of DNA recombination. Localizes to the nucleus. Used to study Lynch syndrome. Human ortholog(s) of this gene implicated in Lynch syndrome; Muir-Torre syndrome; colorectal cancer; hereditary nonpolyposis colorectal cancer type 2; and sporadic breast cancer. Is expressed in genitourinary system. Orthologous to human MLH1 (mutL homolog 1).