Automated description from the Alliance of Genome Resources
Exhibits dystroglycan binding activity. Involved in several processes, including morphogenesis of an epithelium; nervous system development; and retrograde trans-synaptic signaling by trans-synaptic protein complex. Localizes to several cellular components, including the dystroglycan complex; node of Ranvier; and sarcolemma. Predicted to colocalize with the focal adhesion. Used to study autosomal recessive limb-girdle muscular dystrophy type 2P; dilated cardiomyopathy; and lissencephaly. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; Walker-Warburg syndrome; autosomal recessive limb-girdle muscular dystrophy type 2D; autosomal recessive limb-girdle muscular dystrophy type 2P; and inclusion body myositis. Orthologous to human DAG1 (dystroglycan 1).