Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits ATPase activity and DNA binding activity. Contributes to guanine/thymine mispair binding activity. Involved in several processes, including DNA metabolic process; negative regulation of cell cycle; and regulation of DNA recombination. Localizes to MutSalpha complex. Is expressed in several structures, including genitourinary system; heart; liver; lung; and tail dorsal root ganglion. Used to study Lynch syndrome. Human ortholog(s) of this gene implicated in Lynch syndrome (multiple); breast cancer; colorectal cancer; and urinary bladder cancer. Orthologous to human MSH2 (mutS homolog 2).