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Gene Ontology Classifications
ISL1 transcription factor, LIM/homeodomain

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Isl1. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Ahlgren U et al. (1997) Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature, 385:257-60. (PubMed:9000074)
  2. Arber S et al. (1999) Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity [see comments] Neuron, 23:659-74. (PubMed:10482234)
  3. Bach I et al. (1999) RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat Genet, 22:394-9. (PubMed:10431247)
  4. Barzelay A et al. (2012) Islet-1 gene delivery improves myocardial performance after experimental infarction. Atherosclerosis, 223:284-90. (PubMed:22727192)
  5. Bhati M et al. (2008) Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes. EMBO J, 27:2018-29. (PubMed:18583962)
  6. Cai CL et al. (2003) Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell, 5:877-89. (PubMed:14667410)
  7. Dykes IM et al. (2011) Brn3a and islet1 act epistatically to regulate the gene expression program of sensory differentiation. J Neurosci, 31:9789-99. (PubMed:21734270)
  8. Elshatory Y et al. (2008) The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons. J Neurosci, 28:3291-7. (PubMed:18367596)
  9. Hao A et al. (2005) The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities. Mol Biol Cell, 16:1569-83. (PubMed:15659653)
  10. Hao Z et al. (1999) Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord. Dev Dyn, 216:201-17. (PubMed:10536059)
  11. Jensen J et al. (2000) Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes, 49:163-76. (PubMed:10868931)
  12. Kelly CE et al. (2013) Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. PLoS Biol, 11:e1001538. (PubMed:23610558)
  13. Kwon C et al. (2009) A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol, 11:951-7. (PubMed:19620969)
  14. Lin L et al. (2007) Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis. Proc Natl Acad Sci U S A, 104:9313-8. (PubMed:17519333)
  15. Lin L et al. (2006) Isl1 is upstream of sonic hedgehog in a pathway required for cardiac morphogenesis. Dev Biol, 295:756-63. (PubMed:16687132)
  16. Mak KK et al. (2008) Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development, 135:1947-56. (PubMed:18434416)
  17. Mitsiadis TA et al. (2003) Role of Islet1 in the patterning of murine dentition. Development, 130:4451-4460. (PubMed:12900460)
  18. Pan L et al. (2008) ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells. Development, 135:1981-90. (PubMed:18434421)
  19. Pfaff SL et al. (1996) Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell, 84:309-20. (PubMed:8565076)
  20. Song MR et al. (2009) Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity. Development, 136:2923-32. (PubMed:19666821)
  21. Sumazaki R et al. (2004) Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat Genet, 36:83-7. (PubMed:14702043)
  22. Sun Y et al. (2008) A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci, 11:1283-93. (PubMed:18849985)
  23. Takuma N et al. (1998) Formation of Rathke's pouch requires dual induction from the diencephalon. Development, 125:4835-40. (PubMed:9806931)
  24. Thaler JP et al. (2004) A postmitotic role for Isl-class LIM homeodomain proteins in the assignment of visceral spinal motor neuron identity. Neuron, 41:337-50. (PubMed:14766174)

Go Annotations in Tabular Form (Text View) (GO Graph)


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement

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