Automated description from the Alliance of Genome Resources
Exhibits identical protein binding activity and protein serine/threonine kinase activity. Involved in centriole replication; de novo centriole assembly involved in multi-ciliated epithelial cell differentiation; and trophoblast giant cell differentiation. Localizes to the XY body; deuterosome; and nucleolus. Human ortholog(s) of this gene implicated in microcephaly and chorioretinopathy 2. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and musculoskeletal system. Orthologous to human PLK4 (polo like kinase 4).