About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Hmga2
high mobility group AT-hook 2
MGI:101761

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hmga2. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Anand A et al. (2000) In vivo modulation of Hmgic reduces obesity. Nat Genet, 24:377-80. (PubMed:10742101)
  2. Benson KF et al. (1994) Mini-mouse: phenotypic characterization of a transgenic insertional mutant allelic to pygmy. Genet Res, 64:27-33. (PubMed:7958830)
  3. Brants JR et al. (2004) Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2. FEBS Lett, 569:277-83. (PubMed:15225648)
  4. Chieffi P et al. (2002) HMGA1 and HMGA2 protein expression in mouse spermatogenesis. Oncogene, 21:3644-50. (PubMed:12032866)
  5. Cui T et al. (2005) Energetics of binding the mammalian high mobility group protein HMGA2 to poly(dA-dT)2 and poly(dA)-poly(dT). J Mol Biol, 352:629-45. (PubMed:16109425)
  6. De Martino I et al. (2009) HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas. Cancer Res, 69:1844-50. (PubMed:19223528)
  7. Di Agostino S et al. (2004) Phosphorylation of high-mobility group protein A2 by Nek2 kinase during the first meiotic division in mouse spermatocytes. Mol Biol Cell, 15:1224-32. (PubMed:14668482)
  8. Fedele M et al. (2006) HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity. Cancer Cell, 9:459-71. (PubMed:16766265)
  9. KING JW. (1950) Pygmy, a dwarfing gene in the house mouse. J Hered, 41:249-52. (PubMed:14794889)
  10. King JW. (1955) Observations on the mutant "pygmy" in the house mouse. J Genet, 53:487-497.
  11. Lin HH et al. (2007) Transcriptional regulation by targeted expression of architectural transcription factor high mobility group A2 in salivary glands of transgenic mice. Eur J Oral Sci, 115:30-9. (PubMed:17305714)
  12. Nishino J et al. (2008) Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression. Cell, 135:227-39. (PubMed:18957199)
  13. Rimoin DL et al. (1972) The pygmy (pg) mutant of the mouse--a model of the human pygmy. J Clin Endocrinol Metab, 35:467-8. (PubMed:5051369)
  14. Sanosaka T et al. (2008) Identification of genes that restrict astrocyte differentiation of midgestational neural precursor cells. Neuroscience, 155:780-8. (PubMed:18640244)
  15. Sinha YN et al. (1979) Serum and pituitary concentrations of growth hormone and prolactin in pygmy mice. Proc Soc Exp Biol Med, 162:221-3. (PubMed:504232)
  16. Sutherland HG et al. (2001) Large-scale identification of mammalian proteins localized to nuclear sub-compartments. Hum Mol Genet, 10:1995-2011. (PubMed:11555636)
  17. Tessari MA et al. (2003) Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Mol Cell Biol, 23:9104-16. (PubMed:14645522)
  18. Zhou X et al. (1995) Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C [see comments] Nature, 376:771-4. (PubMed:7651535)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory