Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cfl1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cfl1
  • participates in the following biological processes:
    • protein phosphorylation ^[5]
    • response to amino acid stimulus ^[5]
  • is located in the following cellular components:
    • cortical actin cytoskeleton ^{[2, 4]}
    • cytoplasm ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cfl1
  • participates in the following biological processes:
    • actin filament organization ^[1]
    • cellular component movement ^[4]
    • cytokinesis ^[4]
    • establishment of cell polarity ^[1]
    • neural crest cell migration ^[3]
    • neural fold formation ^[3]
    • positive regulation of actin filament depolymerization ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cfl1:
  • participates in the following biological processes:
    • cell projection organization
    • cytoskeleton organization
    • negative regulation of cell size
    • protein import into nucleus
    • regulation of cell morphogenesis
  • performs the following molecular functions:
    • actin binding
  • is located in the following cellular components:
    • cell leading edge
    • cytoplasm
    • lamellipodium

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Summary text based on GO annotations supported by structural data

• Cfl1 encodes a protein or proteins that contain the following InterPro domains: Actin-binding, cofilin/tropomyosin type, ADF/Cofilin/Destrin, indicating that the gene product:
  • participates in the following biological processes:
    • actin filament depolymerization
  • is located in the following cellular components:
    • actin cytoskeleton
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cfl1 indicates that it:
  • is located in the following cellular components:
    • cell projection
    • cytoskeleton
    • membrane
    • nucleus
    • plasma membrane

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References

1. Bailey CD et al. (2005) Tissue transglutaminase contributes to disease progression in the R6/2 Huntington's disease mouse model via aggregate-independent mechanisms. J Neurochem, 92:83-92. (PubMed:15606898)
2. Bertling E et al. (2004) Cyclase-associated protein 1 (CAP1) promotes cofilin-induced actin dynamics in mammalian nonmuscle cells. Mol Biol Cell, 15:2324-34. (PubMed:15004221)
3. Gurniak CB et al. (2005) The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev Biol, 278:231-41. (PubMed:15649475)
4. Hotulainen P et al. (2005) Actin-depolymerizing factor and cofilin-1 play overlapping roles in promoting rapid F-actin depolymerization in mammalian nonmuscle cells. Mol Biol Cell, 16:649-64. (PubMed:15548599)
5. Offenhauser N et al. (2006) Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. Cell, 127:213-26. (PubMed:17018287)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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