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Glossary Term
Glossary Term Endonuclease Mediated Mutation
Definition A type of engineered mutation in which a chromosomal gene is altered by the action of a RNA-guided DNA site-specific endonuclease, including the actions of the clustered regulatory interspaced short palindromic repeat (CRISPR/Cas9 )system, transcription activator-like effector nucleases (TALENS) or zinc finger nucleases (ZFN). These endonucleases induce a broad range of mutations by inducing DNA double-strand breaks that stimulate error-prone nonhomologous end joining (NEJ) or homology-directed repair (HDR) at specified genomic locations.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory