| Glossary Term | Endonuclease Mediated Mutation |
| Definition | A type of engineered mutation in which a chromosomal gene is altered by the action of a RNA-guided DNA site-specific endonuclease, including the actions of the clustered regulatory interspaced short palindromic repeat (CRISPR/Cas9 )system, transcription activator-like effector nucleases (TALENS) or zinc finger nucleases (ZFN). These endonucleases induce a broad range of mutations by inducing DNA double-strand breaks that stimulate error-prone nonhomologous end joining (NEJ) or homology-directed repair (HDR) at specified genomic locations. |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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