ZDF (Reserved symbol)

Inbr. F10.

Origin: "Zucker" fatty rats of undefined outbred background, inbred with selection for non-insulin-dependent diabetes mellitus by mating diabetic homozygous fatty males to heterozygous sisters (Peterson et al 1990b).

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Characteristics

Develops overt diabetes associated with decreased plasma insulin levels. Depending on age can be sub-divided into obese, mildly diabetic (blood glucose <11 mM) and obese severely diabetic (blood glucose >20 mM) groups (Slieker et al, 1992). Develop quantifiable retinal vascular changes (Danis and Yang, 1993)

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Danis R. P. and Yang Y. H. (1993) Microvascular retinopathy in the Zucker diabetic fatty rat. Investigative Ophthalmology & Visual Science 34, 2367-2371. \par

Peterson R. G., Shaw W. N., Neel A.-A., Little L. A., and Eichberg J. (1990b) Zucker diabetic fatty rat as a model for non-insulin-dependent diabetes mellitus. ILAR News 32, 16-19. \par

Slieker L. J., Sundell K. L., Heath W. F., Osborne H. E., Bue J., Manetta J., and Sportsman J. R. (1992) Glucose transporter levels in tissues of spontaneously diabetic Zucker fa fa rat (ZDF/Drt) and viable yellow mouse (A^vy/a). Diabetes 41, 187-193. \par

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK