WCF

Inbr. F204+51 (Idr 1991).

Colour: Albino.

Genet. A,B,c,h.

Origin: R Shoji, 1972 from a male rat of strain WKAH/Idr with clubfoot of the right hind foot.

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Characteristics

Incidence of clubfoot varies, and did not seem to be associated with type of mating. Normal x normal produced 28%, normal x clubfoot produced 25% and clbfoot x clubfoot produced 34% clubfoot offspring, respectively. No causative gene has been isolated. The condition can be detected at the terminal stages of gestation, with abnormalities of the peroneal nerve and the anterior and lateral crural muscles in adult rats (Shoji et al 1988)

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Shoji R., Kimura R., Murata Y., and Hanai A. (1988) Report: Establishment of a new mutant strain of congenital cataract and Hereditary clubfoot spontaneously occurred in WKAH/Idr inbred strain. Rat News Lett. 20, 22.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK