OLETF

Inbr. F46 (Otk, 1996).

Colour: Black hooded

Genet. a,B,C,h.

Origin: Developed by Kazuya Kawano, Otsuka Pharmaceutical Co., Tokushima, Japan from Long-Evans outbred stock in 1983.

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Characteristics

Develops late onset of hyperglycemia (at about 18 weeks of age), hyperinsulinemia and mild obesity, mostly in males, that closely resembles non-insulin-dependent diabetes mellitus in humans associated with a sex-linked gene Odb-1 (Kawano et al, 1994, Hirashima et al, 1995). Has a selective defect in the binding of cholecystokinin-8 to its receptors on the acinar cell surfaces (Otsuki et al, 1995, Funakoshi et al, 1995). Treatment with insulin was effective in preventing B-cell dysfunction and morphological changes of the pancreas (Ishida et al, 1995)

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Funakoshi A., Miyasaka K., Shinozaki H., Masuda M., Kawanami T., Takata Y., and Kono A. (1995) An animal-model of congenital defect of gene-expression of cholecystokinin (CCK)-a receptor. Biochemical and Biophysical Research Communications 210, 787-796.

Hirashima T., Kawano K., Mori S., Matsumoto K., and Natori T. (1995) A diabetogenic gene (Odb-1) assigned to the X-chromosome in OLETF rats. Diabetes Research and Clinical Practice 27, 91-96.

Ishida K., Mizuno A., Sano T., Noma Y., and Shima K. (1995) Effect of timely insulin administration on pancreatic B-cells of Otsuka-Long-Evans-Tokushima-Fatty (OLETF) strain rats - an animal- model of non-insulin-dependent diabetes-mellitus (NIDDM). Hormone and Metabolic Research 27, 398-402.

Kawano K., Hirashima T., Mori S., and Natori T. (1994) OLETF (Otsuka Long-Evans Tokushima Fatty) rat - a new NIDDM rat strain. Diabetes Research and Clinical Practice 24, S317-S320.

Otsuki M., Akiyama T., Shirokara H., Nakano S., Furumi K., and Tachibana I. (1995) Loss of sensitivity to cholecystokinin stimulation of isolated pancreatic acini from genetically diabetic rats. American Journal of Physiology-Endocrinology and Metabolism 31, E531-E536.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK