BS

Inbr. F41 (1988).

Colour: Black.

Genet: a.

Origin: University of Otago Medical School from a cross of wild rats x Wistar stock, with black phenotype backcrossed to the Wistar (Zeiss 1966).

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Characteristics

Docile. Fair reproduction. Low incidence of hydrocephalus. Vieregge et al (1987) found a long pentobrbitone sleeping time in females (2/10) but a short time in males (8/10). Has deficient release of prolactin after stressful stimuli, which may be associated with a deficit in vasoactive intestinal polypeptide and peptide histidine isoleucine in fibres associated with the portal vessels at the median eminence level (Ceccatelli et al, 1992).

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Ceccatelli S., Fahrenkrug J., Eneroth P., and Hokfelt T. (1992) Vasoactive intestinal polypeptide peptide histidine isoleucine- immunoreactive neuron systems in the basal hypothalamus of a rat strain with deficient prolactin-release in response to stress. Journal of Neuroendocrinology 4, 51-58.

Vieregge V. T., Hackbarth H., and Bercher P. (1987) Die Pentobarbitalschlafzeit zur pharmakogenetischen Differenzierung von Ratteninzuchtstammen. Z. Versuchstierk. 29, 209-217.

Zeiss I. M. (1966) Demonstration of isohistogenicity in groups of rats from partially inbred strains. Transplant. 4, 506-509.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK