Symbol
Name
ID

Runx2
runt related transcription factor 2
MGI:99829

Phenotype annotations related to growth/size/body

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Short stature	Moderately short stature	Severe short stature
Disease(s) Associated with RUNX2	Short stature	Moderately short stature	Severe short stature
cleidocranial dysplasia
metaphyseal dysplasia-maxillary hypoplasia-brachydactyly syndrome

Mouse Phenotypes

abnormal incisor morphology

small incisors

abnormal molar morphology

small molars

abnormal tooth development

abnormal dental lamina morphology

abnormal dental papilla morphology

abnormal cervical loop morphology

abnormal enamel knot morphology

arrest of tooth development

growth retardation of incisors

growth retardation of molars

abnormal dentin morphology

abnormal enamel morphology

abnormal nasal bone morphology

nasal bone hypoplasia

palatal shelves fail to meet at midline

cleft secondary palate

abnormal nose morphology

growth/size/body region phenotype

decreased birth weight

decreased birth body size

increased lean body mass

decreased body weight

slow postnatal weight gain

decreased body size

disproportionate dwarf

enlarged spleen

Availability

Mouse Genotype

Runx2^tm1Kish/Runx2^tm1Kish

Runx2^tm1Ldq/Runx2^tm1Ldq

Runx2^tm1Mjo/Runx2^tm1Mjo

Runx2^{em1(IMPC)Rbrc}/Runx2⁺

Runx2^tm1Gss/Runx2⁺

Runx2^tm1Kish/Runx2⁺

Runx2^tm1Ldq/Runx2⁺

Runx2^tm1Mjo/Runx2⁺

Runx2^tm1Javed/Runx2^tm1Javed
Tg(Col2a1-cre)1Bhr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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