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Symbol
Name
ID

Acan
aggrecan
MGI:99602

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes	Genu valgum	Genu varum	Flat capital femoral epiphysis	Micromelia	Delayed skeletal maturation	Abnormal epiphysis morphology	Short thorax	Platyspondyly	Osteoarthritis	Spondyloepiphyseal dysplasia
Disease(s) Associated with ACAN
spondyloepiphyseal dysplasia Kimberley type

Mouse Phenotypes

abnormal craniofacial bone morphology

short basicranium

decreased susceptibility to induced arthritis

short humerus

short femur

short tibia

absent caudal vertebrae

abnormal tracheal cartilage morphology

decreased length of long bones

abnormal rib morphology

abnormal intervertebral disk morphology

intervertebral disk degeneration

kyphosis

lordosis

abnormal vertebrae morphology

abnormal vertebral body morphology

short vertebral column

abnormal trabecular bone morphology

abnormal cartilage development

abnormal chondrocyte morphology

abnormal joint morphology

Availability

Mouse Genotype

Acan^cmd/Acan^cmd

Acan^m2Btlr/Acan^m2Btlr

Acan^mpc227H/Acan^mpc227H

Acan^tm2Afos/Acan^tm2Afos

Acan^cmd/Acan⁺

Acan^m1Btlr/Acan⁺

Acan^m2Btlr/Acan⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23