Symbol
Name
ID

Ptpn11
protein tyrosine phosphatase, non-receptor type 11
MGI:99511

Phenotype annotations related to muscle

Darker colors indicate more annotations

Human Phenotypes	Scapular winging	Aplasia/Hypoplasia of the abdominal wall musculature	Hypotonia	Muscle weakness
Disease(s) Associated with PTPN11	Scapular winging	Aplasia/Hypoplasia of the abdominal wall musculature	Hypotonia	Muscle weakness
Noonan syndrome
Noonan syndrome with multiple lentigines 1

Mouse Phenotypes

increased cardiac muscle triglyceride level

abnormal myocardial fiber morphology

increased myocardial fiber size

myocardial fiber disarray

thin myocardium compact layer

thin myocardium

heart left ventricle hypertrophy

dilated cardiomyopathy

decreased cardiac muscle cell glucose uptake

decreased cardiac muscle contractility

decreased ventricle muscle contractility

increased cardiac muscle contractility

decreased cardiomyocyte apoptosis

cardiomyopathy

ventricular cardiomyopathy

decreased muscle cell glucose uptake

decreased skeletal muscle triglyceride level

increased skeletal muscle triglyceride level

decreased skeletal muscle fiber size

decreased skeletal muscle fiber number

Availability

Mouse Genotype

Ptpn11^tm1Bgn/Ptpn11^tm1Bgn

Ptpn11^tm7Bgn/Ptpn11^tm7Bgn

Ptpn11^tm1.1Ics/Ptpn11⁺

Ptpn11^tm1Bgn/Ptpn11⁺

Ptpn11^tm4.2Bgn/Ptpn11⁺

Tg(Myh7-Ptpn11*Q79R)11Rbns/0

Tg(Myh7-Ptpn11*Q510E)#Krnz/0

Ptpn11^tm1Gsf/Ptpn11^tm1Gsf
Tg(Ckmm-cre)5Khn/0 (conditional)

Ptpn11^tm1Yan/Ptpn11^tm1Yan
Tg(Ckmm-cre)5Khn/0 (conditional)

Meox2^tm1(cre)Sor/Meox2⁺
Ptpn11^tm6Bgn/Ptpn11⁺ (conditional)

Ptpn11^tm6Bgn/Ptpn11⁺
Tg(Tek-cre)12Flv/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23