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Symbol
Name
ID

Ptpn11
protein tyrosine phosphatase, non-receptor type 11
MGI:99511

Phenotype annotations related to hearing/vestibular/ear

Darker colors indicate more annotations

Human Phenotypes	Aplasia of the semicircular canal	Thickened helices	Low-set ears	Low-set, posteriorly rotated ears	Posteriorly rotated ears	Protruding ear	Sensorineural hearing impairment	Hearing impairment
Disease(s) Associated with PTPN11	Aplasia of the semicircular canal	Thickened helices	Low-set ears	Low-set, posteriorly rotated ears	Posteriorly rotated ears	Protruding ear	Sensorineural hearing impairment	Hearing impairment
Noonan syndrome
Noonan syndrome 1
Noonan syndrome with multiple lentigines 1

Mouse Phenotypes		small ears	abnormal organ of Corti morphology
Availability	Mouse Genotype	small ears	abnormal organ of Corti morphology
	Ptpn11^tm4.2Bgn/Ptpn11⁺
	Ptpn11^tm1.1Rbns/Ptpn11^tm1.1Rbns H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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