Symbol
Name
ID

Ptpn11
protein tyrosine phosphatase, non-receptor type 11
MGI:99511

Phenotype annotations related to cellular

Darker colors indicate more annotations

Mouse Phenotypes

abnormal fat cell differentiation

increased adipocyte glucose uptake

cardiac interstitial fibrosis

decreased cardiac muscle cell glucose uptake

decreased cardiomyocyte apoptosis

azoospermia

abnormal spermatocyte morphology

abnormal spermatogonia morphology

decreased male germ cell number

aneuploidy

polyploidy

abnormal cell death

increased male germ cell apoptosis

hepatic necrosis

focal hepatic necrosis

abnormal axon extension

abnormal axon fasciculation

decreased trophectoderm cell proliferation

decreased cell proliferation

increased cell proliferation

increased hepatocyte proliferation

decreased muscle cell glucose uptake

chromosomal instability

Availability

Mouse Genotype

Ptpn11^tm1Bgn/Ptpn11^tm1Bgn

Ptpn11^tm1Paw/Ptpn11^tm1Paw

Ptpn11^tm5Bgn/Ptpn11^tm5Bgn

Ptpn11^tm1.1Ics/Ptpn11⁺

Ptpn11^tm1Bgn/Ptpn11⁺

Tg(Myh7-Ptpn11*Q510E)#Krnz/0

Ptpn11^tm1.1Wbm/Ptpn11^tm1.1Wbm
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Ptpn11^tm1Gsf/Ptpn11^tm1Gsf
Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ (conditional)

Ptpn11^tm1Gsf/Ptpn11^tm1Gsf
Tg(Ckmm-cre)5Khn/0 (conditional)

Ptpn11^tm1Gsf/Ptpn11^tm1Gsf
Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺ (conditional)

Ptpn11^tm1Ckq/Ptpn11⁺
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23