Symbol
Name
ID

Nr3c2
nuclear receptor subfamily 3, group C, member 2
MGI:99459

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Hyperkalemia	Hyponatremia	Metabolic acidosis	Dehydration
Disease(s) Associated with NR3C2
autosomal dominant pseudohypoaldosteronism type 1

Mouse Phenotypes

homeostasis/metabolism phenotype

increased circulating angiotensin II level

increased circulating aldosterone level

increased circulating potassium level

decreased circulating sodium level

increased circulating renin level

dehydration

abnormal ion homeostasis

abnormal renal sodium reabsorption

increased urine sodium level

increased renin activity

Availability

Mouse Genotype

Nr3c2^tm1Gsc/Nr3c2^tm1Gsc

Nr3c2^tm1Gsc/Nr3c2⁺

Nr3c2^tm2Gsc/Nr3c2^tm2Gsc
Tg(Aqp2-cre/ERT2)4Gsc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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