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Symbol
Name
ID
Trp53
transformation related protein 53
MGI:98834
Phenotype annotations related to cellular
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA level
Increased circulating IgG level
Decreased circulating antibody level
Paraproteinemia
Disease(s) Associated with TP53
multiple myeloma

Mouse Phenotypes
cellular phenotype
abnormal chromosome number
aneuploidy
polyploidy
decreased telomere length
abnormal mitochondrial morphology
abnormal cell physiology
abnormal cell cycle
abnormal cell cycle checkpoint function
abnormal cell death
decreased sensitivity to induced cell death
decreased cellular sensitivity to ionizing radiation
decreased cellular sensitivity to gamma-irradiation
decreased cellular sensitivity to ultraviolet irradiation
increased sensitivity to induced cell death
increased cellular sensitivity to DNA damaging agents
increased cellular sensitivity to ionizing radiation
abnormal apoptosis
abnormal thymocyte apoptosis
decreased thymocyte apoptosis
increased thymocyte apoptosis
decreased T cell apoptosis
decreased fibroblast apoptosis
decreased enterocyte apoptosis
increased enterocyte apoptosis
abnormal male germ cell apoptosis
decreased neuron apoptosis
decreased splenocyte apoptosis
decreased apoptosis
increased apoptosis
abnormal neuron differentiation
abnormal cell migration
abnormal cell proliferation
decreased T cell proliferation
increased fibroblast proliferation
decreased hematopoietic stem cell proliferation
increased splenocyte proliferation
decreased cell proliferation
increased cell proliferation
increased cellular glucose import
delayed cellular replicative senescence
early cellular replicative senescence
increased DNA replication
chromosomal instability
spontaneous chromosome breakage
oxidative stress
Availability Mouse Genotype
Gt(ROSA)26Sortm1.1(CAG-Trp53*,-EGFP)Medz/Gt(ROSA)26Sortm1.1(CAG-Trp53*,-EGFP)Medz
Trp53tm1.1Dgj/Trp53tm1.1Dgj
Trp53tm1.1Hwan/Trp53tm1.1Hwan
Trp53tm1.1Manf/Trp53tm1.1Manf
Trp53tm1.1Thst/Trp53tm1.1Thst
Trp53tm1.1Tldo/Trp53tm1.1Tldo
Trp53tm1.1Wgu/Trp53tm1.1Wgu *
Trp53tm1.2Awbr/Trp53tm1.2Awbr
Trp53tm1Adv/Trp53tm1Adv
Trp53tm1Att/Trp53tm1Att
Trp53tm1Brd/Trp53tm1Brd
Trp53tm1Gev/Trp53tm1Gev
Trp53tm1Glo/Trp53tm1Glo
Trp53tm1Holl/Trp53tm1Holl *
Trp53tm1Mlh/Trp53tm1Mlh *
Trp53tm1Sia/Trp53tm1Sia
Trp53tm1Thst/Trp53tm1Thst
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Trp53)1Srn/0
Trp53tm1Tyj/Trp53tm1Tyj
Trp53tm1Wahl/Trp53tm1Wahl
Trp53tm1Xu/Trp53tm1Xu
Trp53tm1Yjc/Trp53tm1Yjc
Trp53tm2.1Kasa/Trp53tm2.1Kasa *
Trp53tm2.1Snj/Trp53tm2.1Snj
Trp53tm2.1Wgu/Trp53tm2.1Wgu *
Trp53tm2Glo/Trp53tm2Glo
Trp53tm2Xu/Trp53tm2Xu
Trp53tm3.1Glo/Trp53tm3.1Glo
Trp53tm3Wahl/Trp53tm3Wahl
Trp53tm3Xu/Trp53tm3Xu
Trp53tm4Tyj/Trp53tm4Tyj
Trp53tm4Xu/Trp53tm4Xu
Trp53tm5Tyj/Trp53tm5Tyj *
Trp53tm5Wahl/Trp53tm5Wahl *
Trp53tm5Xu/Trp53tm5Xu
Trp53tm6Wahl/Trp53tm6Wahl *
Trp53tm7.1Xu/Trp53tm7.1Xu
Trp53tm1Adv/Trp53+
Trp53tm1Brd/Trp53+
Trp53tm1Brd/Trp53tm8Xu
Trp53tm1Holl/Trp53tm7.1Xu
Trp53tm1Ldo/Trp53+
Trp53tm1Tyj/Trp53+
Trp53tm1Tyj/Trp53tm1.1Umol
Trp53tm1Tyj/Trp53tm2.1Umol
Trp53tm2.1Snj/Trp53+
Trp53tm2.1Tyj/Trp53+
Trp53tm2Mok/Trp53+
Trp53tm3.1Glo/Trp53+
Trp53tm3.1Tyj/Trp53+
Trp53tm4Xu/Trp53+ *
Trp53tm7.1Xu/Trp53+
Tg(Trp53)1Srn/0
Tg(Trp53)bSrn/0
Tg(Trp53R172H)8512Jmr/0
Trp53tm1.1Brn/Trp53tm1.1Brn
Tg(KRT14-cre)8Brn/?  (conditional)
Trp53tm1Att/Trp53tm1Att
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/?  (conditional)
Trp53tm1Brn/Trp53tm1Brn  (conditional) *
Trp53tm2Att/Trp53tm2Att  (conditional)
Trp53tm2Tyj/Trp53tm2Tyj  (conditional)
Trp53tm3Att/Trp53tm3Att  (conditional) *
Trp53tm3Att/Trp53tm3Att
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/?  (conditional)
*
Trp53tm3Tyj/Trp53tm3Tyj  (conditional)
Trp53tm4Att/Trp53tm4Att  (conditional)
Trp53tm4Att/Trp53tm4Att
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/?  (conditional)
Trp53tm1.1Brn/Trp53+
Tg(KRT14-cre)8Brn/?  (conditional)
Trp53tm1.1Brn/Trp53tm3Tyj
Tg(KRT14-cre)8Brn/?  (conditional)
Trp53tm1Brn/Trp53tm2Tyj  (conditional)
Trp53tm1Tyj/Trp53tm1.1Dgk  (conditional)
Trp53tm3Tyj/Trp53+
Tg(KRT14-cre)8Brn/?  (conditional)
Tg(CMV-cre)1Cgn/0
Trp53tm4Att/Trp53+  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory