|
Symbol Name ID |
Spp1
secreted phosphoprotein 1 MGI:98389 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgG level |
Decreased circulating antibody level |
Paraproteinemia |
Hypercalcemia |
Hyperbilirubinemia |
Conjugated hyperbilirubinemia |
Increased total bilirubin |
Unconjugated hyperbilirubinemia |
Elevated circulating creatinine concentration |
Elevated circulating C-reactive protein concentration |
Hyperproteinemia |
Elevated circulating hepatic transaminase concentration |
Elevated gamma-glutamyltransferase level |
Elevated circulating alkaline phosphatase concentration |
Elevated erythrocyte sedimentation rate |
Diabetes mellitus |
Joint swelling |
Pleural effusion |
Fever |
Abnormality of vitamin B12 metabolism |
Acholic stools |
Dark yellow urine |
Amyloidosis |
| Disease(s) Associated with SPP1 | ||||||||||||||||||||||||
| biliary atresia | ||||||||||||||||||||||||
| multiple myeloma | ||||||||||||||||||||||||
| pancreatic cancer | ||||||||||||||||||||||||
| rheumatoid arthritis |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
abnormal response to cardiac infarction |
abnormal vascular wound healing |
decreased susceptibility to dopaminergic neuron neurotoxicity |
increased circulating creatinine level |
increased blood urea nitrogen level |
decreased circulating glucose level |
decreased circulating insulin level |
decreased circulating triglyceride level |
decreased circulating interleukin-6 level |
increased respiratory quotient |
improved glucose tolerance |
increased insulin sensitivity |
decreased urine chloride ion level |
decreased urine sodium level |
abnormal chemokine level |
crystalluria |
decreased physiological sensitivity to xenobiotic |
decreased incidence of tumors by chemical induction |
increased physiological sensitivity to xenobiotic |
abnormal wound healing |
delayed wound healing |
increased susceptibility to injury |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||
| Spp1tm1Blh/Spp1tm1Blh | * | |||||||||||||||||||||||
| Spp1tm1Rit/Spp1tm1Rit | ||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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