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Symbol Name ID |
Sparc
secreted acidic cysteine rich glycoprotein MGI:98373 |
| Darker colors indicate more annotations |
| Human Phenotypes | Dentinogenesis imperfecta |
Bowed humerus |
Thin long bone diaphyses |
Thin metacarpal cortices |
Hip dislocation |
Joint hypermobility |
Bone pain |
Pathologic fracture |
Recurrent fractures |
Kyphoscoliosis |
Platyspondyly |
Vertebral compression fracture |
Reduced bone mineral density |
Osteopenia |
Osteoporosis |
| Disease(s) Associated with SPARC | |||||||||||||||
| multiple myeloma | |||||||||||||||
| osteogenesis imperfecta type 17 |
| Mouse Phenotypes | abnormal tooth morphology |
abnormal incisor color |
decreased osteoclast cell number |
abnormal osteoclast morphology |
abnormal humerus morphology |
abnormal tibia morphology |
abnormal skeleton morphology |
decreased bone mineral content |
decreased bone mineral density |
abnormal osteoblast morphology |
decreased osteoblast cell number |
abnormal trabecular bone morphology |
abnormal skeleton physiology |
abnormal bone remodeling |
abnormal bone strength |
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| Availability | Mouse Genotype | |||||||||||||||
| Sparctm1a(EUCOMM)Wtsi/Sparctm1a(EUCOMM)Wtsi | ||||||||||||||||
| Sparctm1Hwe/Sparctm1Hwe | ||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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