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Symbol
Name
ID 		Sod2
superoxide dismutase 2, mitochondrial
MGI:98352
Phenotype annotations related to vision/eye
Darker colors indicate more annotations
Human Phenotypes
Retinal hemorrhage
Central retinal vessel vascular tortuosity
Choroidal neovascularization
Optic atrophy
Optic disc drusen
Leber optic atrophy
Optic neuropathy
Macular degeneration
Angioid streaks of the fundus
Retinal peau d'orange
Retinopathy
Blue sclerae
Myopia
Metamorphopsia
Visual impairment
Reduced visual acuity
Centrocecal scotoma
Visual loss
Progressive visual loss
Open angle glaucoma
Disease(s) Associated with SOD2
Leber hereditary optic neuropathy
neuronal ceroid lipofuscinosis
primary open angle glaucoma
pseudoxanthoma elasticum
systemic lupus erythematosus

Mouse Phenotypes
abnormal retina vasculature morphology
retina hemorrhage
short photoreceptor inner segment
short photoreceptor outer segment
abnormal retina rod cell outer segment morphology
retina photoreceptor degeneration
abnormal optic nerve morphology
abnormal retina pigment epithelium morphology
abnormal retina pigmentation
retina pigment epithelium atrophy
abnormal ocular fundus morphology
abnormal retina morphology
thin retina inner nuclear layer
thin retina outer nuclear layer
abnormal retina photoreceptor layer morphology
retina degeneration
abnormal optic choroid morphology
abnormal Bruch membrane morphology
decreased a-wave amplitude
decreased b-wave amplitude
abnormal cone electrophysiology
abnormal rod electrophysiology
Availability Mouse Genotype
Sod2tm1Cje/Sod2tm1Cje
Sod2tm1Kskk/Sod2tm1Kskk
Tg(BEST1-rtTA,tetO-cre)1Yzl/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory