Symbol Name ID |
Sod2
superoxide dismutase 2, mitochondrial MGI:98352 |
* | Aspects of the system are reported to show a normal phenotype. |
! | Indicates phenotype varies with strain background. |
Darker colors indicate more annotations |
Human Phenotypes | Quadriceps muscle weakness |
Spasticity |
EMG abnormality |
Distal muscle weakness |
Generalized muscle weakness |
Proximal muscle weakness |
Abnormal muscle fiber morphology |
Ragged-red muscle fibers |
Rimmed vacuoles |
Skeletal muscle atrophy |
Myopathy |
Inflammatory myopathy |
Disease(s) Associated with SOD2 | ||||||||||||
inclusion body myositis | ||||||||||||
Leber hereditary optic neuropathy | ||||||||||||
multiple myeloma | ||||||||||||
neuronal ceroid lipofuscinosis |
Mouse Phenotypes | muscle phenotype |
abnormal cardiac muscle tissue morphology |
increased cardiac muscle glycogen level |
abnormal myocardium layer morphology |
abnormal myocardial fiber morphology |
myocardial fiber degeneration |
myocardial fiber disarray |
cardiac muscle necrosis |
dilated cardiomyopathy |
decreased cardiac muscle contractility |
increased cardiomyocyte apoptosis |
abnormal skeletal muscle fiber mitochondrial morphology |
increased muscle cell glucose uptake |
abnormal tibialis anterior morphology |
abnormal skeletal muscle fiber morphology |
decreased skeletal muscle fiber size |
abnormal skeletal muscle morphology |
decreased skeletal muscle mass |
abnormal muscle physiology |
abnormal muscle contractility |
hypotonia |
increased muscle fatigability |
|
Availability | Mouse Genotype | ||||||||||||||||||||||
Sod2tm1.1Kskk/Sod2tm1.1Kskk | |||||||||||||||||||||||
Sod2tm1Cje/Sod2tm1Cje | ! | ||||||||||||||||||||||
Sod2tm1Leb/Sod2tm1Leb | |||||||||||||||||||||||
Sod2tm1.1Kskk/Sod2+ | |||||||||||||||||||||||
Sod2tm1Shs/Sod2tm1Shs Tg(TNNI2-icre)1Vrmn/0 (conditional) |
* | ||||||||||||||||||||||
Sod2tm1Shs/Sod2tm1Shs Tg(Ckmm-cre)5Khn/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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