Symbol
Name
ID

Scn1a
sodium channel, voltage-gated, type I, alpha
MGI:98246

Phenotype annotations related to mortality/aging

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Sudden unexpected death in epilepsy
Disease(s) Associated with SCN1A	Sudden unexpected death in epilepsy
developmental and epileptic encephalopathy 6B

Mouse Phenotypes		increased susceptibility to induced morbidity/mortality	premature death	lethality throughout fetal growth and development, incomplete penetrance	neonatal lethality	postnatal lethality	postnatal lethality, complete penetrance	postnatal lethality, incomplete penetrance	preweaning lethality, incomplete penetrance
Availability	Mouse Genotype	increased susceptibility to induced morbidity/mortality	premature death		neonatal lethality	postnatal lethality	postnatal lethality, complete penetrance	postnatal lethality, incomplete penetrance	preweaning lethality, incomplete penetrance
	Scn1a^em1Anord/Scn1a^em1Anord
	Scn1a^tm1.1Aesc/Scn1a^tm1.1Aesc
	Scn1a^tm1.1Swl/Scn1a^tm1.1Swl
	Scn1a^tm1Kzy/Scn1a^tm1Kzy
	Scn1a^tm1Wac/Scn1a^tm1Wac
	Scn1a^tm1Wac/Scn1a^tm1Wac Tg(Scn1a*)RH9Aesc/0
	Scn1a^tm2.2Kzy/Scn1a^tm2.2Kzy
	Scn1a^tm1.1Kzy/Scn1a⁺
	Scn1a^tm1.1Swl/Scn1a⁺		!
	Scn1a^tm1Kea/Scn1a⁺		!
	Scn1a^tm1Kzy/Scn1a⁺
	Scn1a^tm1Wac/Scn1a⁺		!
	Scn1a^tm1Wac/Scn1a⁺ Tg(Scn1a*)RH9Aesc/0
	Scn1a^tm2.2Kzy/Scn1a⁺
	Scn1a^tm2.1Kzy/Scn1a^tm2.1Kzy Tg(Slc32a1-cre)65Kzy/0 (conditional)
	Emx1^{tm1.1(cre)Ito}/Emx1⁺ Scn1a^tm2.1Kzy/Scn1a^tm2.1Kzy Tg(Slc32a1-cre)65Kzy/0 (conditional)
	Scn1a^tm2.1Kzy/Scn1a^tm2.1Kzy Tg(Pvalb-cre)1Tama/0 (conditional)
	Scn1a^tm2.1Kzy/Scn1a⁺ Tg(Slc32a1-cre)65Kzy/0 (conditional)
	Scn1a^tm2.1Kzy/Scn1a⁺ Tg(Pvalb-cre)1Tama/0 (conditional)
	Scn1a^tm2.1Wac/Scn1a⁺ Tg(I12b-cre)1Jlr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23