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Symbol
Name
ID 		Ptgs2
prostaglandin-endoperoxide synthase 2
MGI:97798
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating antibody level
Hypercalcemia
Elevated circulating C-reactive protein concentration
Increased CSF protein concentration
Elevated circulating hepatic transaminase concentration
Elevated erythrocyte sedimentation rate
Diabetes mellitus
Elevated sweat chloride
Dehydration
Joint swelling
Pleural effusion
Chylothorax
Fever
Hypothermia
Hypercalciuria
Scarring
Disease(s) Associated with PTGS2
cystic fibrosis
idiopathic pulmonary fibrosis
pancreatic cancer
rheumatoid arthritis
sarcoidosis

Mouse Phenotypes
homeostasis/metabolism phenotype
impaired exercise endurance
abnormal response of heart to induced stress
decreased susceptibility to neuronal excitotoxicity
increased susceptibility to neuronal excitotoxicity
intestinal edema
increased susceptibility to diet-induced obesity
decreased platelet calcium level
abnormal platelet physiology
increased platelet aggregation
increased circulating creatinine level
increased blood urea nitrogen level
increased circulating follicle stimulating hormone level
increased circulating luteinizing hormone level
increased circulating insulin level
increased circulating leptin level
abnormal blood coagulation
abnormal thrombolysis
abnormal thrombosis
decreased susceptibility to induced thrombosis
increased susceptibility to induced thrombosis
impaired febrile response
abnormal enzyme/coenzyme level
decreased lactate dehydrogenase level
abnormal lipid homeostasis
decreased prostaglandin level
increased prostaglandin level
abnormal urine homeostasis
decreased urine prostaglandin level
increased urine prostaglandin level
albuminuria
abnormal response/metabolism to endogenous compounds
increased susceptibility to xenobiotic induced morbidity/mortality
decreased physiological sensitivity to xenobiotic
decreased incidence of tumors by chemical induction
increased incidence of tumors by chemical induction
abnormal response to injury
abnormal response to CNS ischemic injury
decreased cerebral infarct size
abnormal wound healing
abnormal bone healing
decreased susceptibility to injury
increased susceptibility to injury
Availability Mouse Genotype
Ptgs2tm1.1Fun/Ptgs2tm1.1Fun
Ptgs2tm1.1Wls/Ptgs2tm1.1Wls
Ptgs2tm1Fun/Ptgs2tm1Fun
Ptgs2tm1Jed/Ptgs2tm1Jed *
Ptgs2tm1Unc/Ptgs2tm1Unc * !
Ptgs2tm3Fun/Ptgs2tm3Fun
Ptgs2tm1Unc/Ptgs2+
Ptgs2tm1Unc/Ptgs2tm2.1Hahe
Tg(K5-Ptgs2)19Kmd/0
Tg(K5-Ptgs2)667Kmd/0
Tg(K5-Ptgs2)675Kmd/0
Tg(Nphs1-Ptgs2)14Rhrs/0
Ptgs2tm1Gaf/Ptgs2tm1Gaf
A1cfTg(Myh6-cre/Esr1*)1Jmk/?  (conditional)
Ptgs2tm1Wlf/Ptgs2tm1Wlf
Tg(Nes-cre)1Kln/0  (conditional)		 *
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory