Symbol
Name
ID

Ptgs2
prostaglandin-endoperoxide synthase 2
MGI:97798

Phenotype annotations related to growth/size/body

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Hepatosplenomegaly	Hepatomegaly	Peritoneal abscess	Decreased body mass index	Failure to thrive	Weight loss
Disease(s) Associated with PTGS2	Hepatosplenomegaly	Hepatomegaly	Peritoneal abscess	Decreased body mass index	Failure to thrive	Weight loss
cystic fibrosis
pancreatic cancer
rheumatoid arthritis
sarcoidosis

Mouse Phenotypes

increased heart weight

growth/size/body region phenotype

weight loss

increased body weight

kidney cyst

kidney cortex cyst

kidney corticomedullary cyst

renal glomerulus cyst

increased susceptibility to diet-induced obesity

enlarged spleen

spleen hyperplasia

Availability

Mouse Genotype

Ptgs2^tm1Jed/Ptgs2^tm1Jed

Ptgs2^tm1Unc/Ptgs2^tm1Unc

Ptgs2^tm1Unc/Ptgs2⁺

Ptgs2^tm1Gaf/Ptgs2^tm1Gaf
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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