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Symbol
Name
ID
Prnp
prion protein
MGI:97769
Phenotype annotations related to behavior/neurological
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Aggressive behavior
Apathy
Irritability
Delusions
Hallucinations
Anxiety
Depressivity
Emotional lability
Perseveration
Personality changes
Psychosis
Restlessness
Insomnia
Disease(s) Associated with PRNP
Creutzfeldt-Jakob disease
fatal familial insomnia
Gerstmann-Straussler-Scheinker syndrome
Huntington's disease-like 1

Mouse Phenotypes
behavior/neurological phenotype
abnormal behavior
abnormal object recognition memory
abnormal spatial working memory
abnormal response to novel object
decreased grooming behavior
excessive scratching
impaired righting response
limb grasping
tremors
ataxia
impaired balance
impaired coordination
paraparesis
abnormal voluntary movement
decreased vertical activity
hyperactivity
hypoactivity
lethargy
abnormal gait
abnormal tail movements
hindlimb paralysis
paresis
circling
abnormal sleep pattern
myoclonus
Availability Mouse Genotype
Prnp/Prndtm1Aag/Prnp/Prndtm1Aag *
Prnptm1Cwe/Prnptm1Cwe *
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)c35Cwe/0
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp)37Jcol/?
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*D177N*M128V)A21Rchi/Tg(Prnp*D177N*M128V)A21Rchi
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*D177N*M128V)A21Rchi/0
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*A116V*M128V)1309Jama/0
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*)#Rgab/0
Prnptm1Cwe/Prnptm1Cwe
Tg(Prnp*S170N*N174T)1020Aag/0
Prnptm1Ito/Prnptm1Ito
Prnptm1Miy/Prnptm1Miy
Prnptm1Wsj/Prnptm1Wsj *
Prnptm2.1Cwe/Prnptm2.1Cwe
Prnptm2Lnq/Prnptm2Lnq
Prnptm2Rcm/Prnptm2Rcm
Prnptm3Lnq/Prnptm3Lnq
Tg(Prnp)1D4Lnq/Tg(Prnp)1D4Lnq
Tg(Prnp*D177N*M128V)A21Rchi/Tg(Prnp*D177N*M128V)A21Rchi
Prnptm1Cwe/Prnptm2.1Cwe
Tg(Prnp)1D4Lnq/0
Tg(Prnp)2D1Lnq/0
Tg(Prnp*)#Rgab/0
Tg(Prnp*D177N*M128V)A21Rchi/0
Tg(Prnp*P101L)174Sbp/0
Tg(Prnp*P101L)2247Sbp/0
Tg(Prnp*P101L)2862Sbp/0
Prnptm1Cwe/Prnptm1Cwe
Tg(Nefh-cre)22Jcol/?
Tg(Prnp)46Jcol/?  (conditional)
*
Prnptm1Cwe/Prnptm1Cwe
Tg(Nefh-cre)22Jcol/?
Tg(Prnp)37Jcol/?  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory