|
Symbol Name ID |
Prnp
prion protein MGI:97769 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Depression |
Emotional lability |
Mania |
Atypical behavior |
Apathy |
Personality changes |
Aggressive behavior |
Restlessness |
| Disease(s) Associated with PRNP | ||||||||
| Creutzfeldt-Jakob disease | ||||||||
| Gerstmann-Straussler-Scheinker syndrome | ||||||||
| Huntington's disease-like 1 |
| Mouse Phenotypes | behavior/neurological phenotype |
abnormal behavior |
lethargy |
abnormal object recognition memory |
abnormal spatial working memory |
abnormal response to novel object |
decreased grooming behavior |
excessive scratching |
impaired righting response |
limb grasping |
tremors |
ataxia |
impaired balance |
impaired coordination |
abnormal tail movements |
abnormal voluntary movement |
abnormal gait |
decreased vertical activity |
decreased locomotor activity |
hyperactivity |
hindlimb paralysis |
paresis |
paraparesis |
circling |
abnormal sleep duration |
abnormal sleep pattern |
myoclonus |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||
| Prnp/Prndtm1Aag/Prnp/Prndtm1Aag | * | |||||||||||||||||||||||||||
| Prnptm1Cwe/Prnptm1Cwe | * | |||||||||||||||||||||||||||
| Prnptm1Cwe/Prnptm1Cwe Tg(Prnp)c35Cwe/0 |
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| Prnptm1Cwe/Prnptm1Cwe Tg(Prnp)37Jcol/? |
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| Prnptm1Cwe/Prnptm1Cwe Tg(Prnp*D177N*M128V)A21Rchi/Tg(Prnp*D177N*M128V)A21Rchi |
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| Prnptm1Cwe/Prnptm1Cwe Tg(Prnp*D177N*M128V)A21Rchi/0 |
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| Prnptm1Cwe/Prnptm1Cwe Tg(Prnp*A116V*M128V)1309Jama/0 |
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| Prnptm1Cwe/Prnptm1Cwe Tg(Prnp*)#Rgab/0 |
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| Prnptm1Cwe/Prnptm1Cwe Tg(Prnp*S170N*N174T)1020Aag/0 |
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| Prnptm1Ito/Prnptm1Ito | ||||||||||||||||||||||||||||
| Prnptm1Miy/Prnptm1Miy | ||||||||||||||||||||||||||||
| Prnptm1Wsj/Prnptm1Wsj | * | |||||||||||||||||||||||||||
| Prnptm2.1Cwe/Prnptm2.1Cwe | ||||||||||||||||||||||||||||
| Prnptm2Lnq/Prnptm2Lnq | ||||||||||||||||||||||||||||
| Prnptm2Rcm/Prnptm2Rcm | ||||||||||||||||||||||||||||
| Prnptm3Lnq/Prnptm3Lnq | ||||||||||||||||||||||||||||
| Tg(Prnp)1D4Lnq/Tg(Prnp)1D4Lnq | ||||||||||||||||||||||||||||
| Tg(Prnp*D177N*M128V)A21Rchi/Tg(Prnp*D177N*M128V)A21Rchi | ||||||||||||||||||||||||||||
| Prnptm1Cwe/Prnptm2.1Cwe | ||||||||||||||||||||||||||||
| Tg(Prnp)1D4Lnq/0 | ||||||||||||||||||||||||||||
| Tg(Prnp)2D1Lnq/0 | ||||||||||||||||||||||||||||
| Tg(Prnp*)#Rgab/0 | ||||||||||||||||||||||||||||
| Tg(Prnp*D177N*M128V)A21Rchi/0 | ||||||||||||||||||||||||||||
| Tg(Prnp*P101L)174Sbp/0 | ||||||||||||||||||||||||||||
| Tg(Prnp*P101L)2247Sbp/0 | ||||||||||||||||||||||||||||
| Tg(Prnp*P101L)2862Sbp/0 | ||||||||||||||||||||||||||||
| Prnptm1Cwe/Prnptm1Cwe Tg(Nefh-cre)22Jcol/? Tg(Prnp)46Jcol/? (conditional) |
* | |||||||||||||||||||||||||||
| Prnptm1Cwe/Prnptm1Cwe Tg(Nefh-cre)22Jcol/? Tg(Prnp)37Jcol/? (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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