Symbol
Name
ID

Abcb4
ATP-binding cassette, sub-family B member 4
MGI:97569

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgA level

Increased circulating IgM level

Conjugated hyperbilirubinemia

Increased serum bile acid concentration

Increased serum bile acid concentration during pregnancy

Abnormal circulating lipid concentration

Hypercholesterolemia

Hypoalbuminemia

Elevated circulating hepatic transaminase concentration

Abnormal liver function tests during pregnancy

Elevated gamma-glutamyltransferase level

Elevated circulating alkaline phosphatase concentration

Ascites

Disease(s) Associated with ABCB4

intrahepatic cholestasis of pregnancy 3

primary biliary cholangitis

progressive familial intrahepatic cholestasis 3

Mouse Phenotypes

homeostasis/metabolism phenotype

decreased intestinal cholesterol absorption

increased circulating creatinine level

abnormal blood homeostasis

abnormal circulating bilirubin level

increased circulating bilirubin level

decreased circulating glucose level

decreased circulating HDL cholesterol level

decreased circulating cholesterol level

decreased circulating calcium level

increased circulating phosphate level

increased circulating potassium level

abnormal circulating enzyme level

abnormal circulating alanine transaminase level

increased circulating alanine transaminase level

abnormal circulating alkaline phosphatase level

increased circulating alkaline phosphatase level

increased circulating amylase level

abnormal circulating aspartate transaminase level

increased circulating aspartate transaminase level

abnormal sodium ion homeostasis

abnormal lipid homeostasis

increased bile salt level

decreased vitamin D level

increased transforming growth factor beta level

increased tumor necrosis factor (ligand) superfamily member 11 level

abnormal enzyme/coenzyme activity

increased alkaline phosphatase activity

Availability

Mouse Genotype

Abcb4^em1(IMPC)H/Abcb4^em1(IMPC)H

Abcb4^tm1Bor/Abcb4^tm1Bor

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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