Symbol
Name
ID

Pde6b
phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
MGI:97525

Phenotype annotations related to vision/eye

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Attenuation of retinal blood vessels	Cataract	Abnormal fundus morphology	Bone spicule pigmentation of the retina	Congenital stationary night blindness	Rod-cone dystrophy	Abnormal light- and dark-adapted electroretinogram	Moderate myopia	Nyctalopia	Reduced visual acuity
Disease(s) Associated with PDE6B	Attenuation of retinal blood vessels	Cataract	Abnormal fundus morphology	Bone spicule pigmentation of the retina	Congenital stationary night blindness	Rod-cone dystrophy	Abnormal light- and dark-adapted electroretinogram	Moderate myopia	Nyctalopia	Reduced visual acuity
congenital stationary night blindness autosomal dominant 2
retinitis pigmentosa 40

Mouse Phenotypes

vision/eye phenotype

impaired pupillary reflex

abnormal retina artery morphology

abnormal retina vasculature morphology

abnormal retina blood vessel morphology

abnormal Muller cell morphology

decreased retina photoreceptor cell number

absent retina rod cells

abnormal photoreceptor outer segment morphology

absent photoreceptor outer segment

abnormal retina cone cell morphology

abnormal retina rod cell morphology

retina rod cell degeneration

retina photoreceptor degeneration

abnormal optic disk morphology

abnormal ocular fundus morphology

abnormal retina morphology

thin retina ganglion layer

thin retina inner plexiform layer

abnormal retina nerve fiber layer morphology

abnormal retina outer nuclear layer morphology

thin retina outer nuclear layer

retina outer nuclear layer degeneration

thin retina outer plexiform layer

abnormal retina photoreceptor layer morphology

increased susceptibility to age-related retinal degeneration

decreased total retina thickness

retina degeneration

abnormal eye physiology

abnormal eye electrophysiology

abnormal cone electrophysiology

abnormal rod electrophysiology

decreased visual acuity

blindness

Availability

Mouse Genotype

Pde6b^atrd1/Pde6b^atrd1

Pde6b^atrd2/Pde6b^atrd2

Pde6b^atrd3/Pde6b^atrd3

Pde6b^rd1-1H/Pde6b^rd1-1H

Pde6b^rd1-2H/Pde6b^rd1-2H

Pde6b^rd1-2J/Pde6b^rd1-2J

Pde6b^rd1-3H/Pde6b^rd1-3H

Pde6b^rd1-4H/Pde6b^rd1-4H

Pde6b^rd1/Pde6b^rd1

Pde6b^rd10/Pde6b^rd10

Pde6b^atrd1/Pde6b^rd1

Pde6b^atrd1/Pde6b^tm1Eye

Pde6b^atrd2/Pde6b^rd1

Pde6b^atrd3/Pde6b^rd1

Pde6b^rd1-1H/Pde6b^rd1

Pde6b^rd1-2H/Pde6b^rd1

Pde6b^rd1-3H/Pde6b^rd1

Pde6b^rd1-4H/Pde6b^rd1

Pde6b^rd1/Pde6b^rgsc1754

Pde6b^atrd1/Pde6b^tm1Eye
Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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