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Symbol Name ID |
Otx2
orthodenticle homeobox 2 MGI:97451 |
| Darker colors indicate more annotations |
| Human Phenotypes | Joint hypermobility |
Delayed skeletal maturation |
Osteoporosis of vertebrae |
Osteopenia |
| Disease(s) Associated with OTX2 | ||||
| panhypopituitarism | ||||
| syndromic microphthalmia 5 |
| Mouse Phenotypes | abnormal cranium morphology |
abnormal basisphenoid bone morphology |
basisphenoid bone foramen |
abnormal Meckel's cartilage morphology |
small cranium |
frontal bone foramen |
abnormal alisphenoid bone morphology |
absent orbitosphenoid bone |
abnormal presphenoid bone morphology |
abnormal pterygoid bone morphology |
abnormal temporal bone tympanic part morphology |
abnormal mandible morphology |
absent mandibular coronoid process |
absent mandible |
micrognathia |
abnormal incus morphology |
abnormal malleus morphology |
abnormal nasal capsule morphology |
absent nasal capsule |
failure of intramembranous bone ossification |
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| Availability | Mouse Genotype | ||||||||||||||||||||
| Otx2tm1Sia/Otx2+ | |||||||||||||||||||||
| Otx2tm1Sia/Otx2tm4Sia | |||||||||||||||||||||
| H2az2Tg(Wnt1-cre)11Rth/H2az2+ Tg(CAG-Otx2,-EGFP)1Eno/? (conditional) |
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| Otx2tm1.1Tlam/Otx2tm2(cre/ERT2)Tlam (conditional) | |||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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