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Symbol
Name
ID

Otx2
orthodenticle homeobox 2
MGI:97451

Phenotype annotations related to growth/size/body

Darker colors indicate more annotations

Human Phenotypes	Delayed puberty	Short stature	Pituitary dwarfism	Growth delay
Disease(s) Associated with OTX2	Delayed puberty	Short stature	Pituitary dwarfism	Growth delay
panhypopituitarism
syndromic microphthalmia 5

Mouse Phenotypes

abnormal nasal capsule morphology

absent nasal capsule

abnormal facial morphology

abnormal palate morphology

absent tongue

abnormal nasal cavity morphology

abnormal nasal septum morphology

abnormal vomeronasal organ morphology

absent vomeronasal organ

absent nasal septum

abnormal olfactory epithelium morphology

abnormal snout morphology

short snout

embryonic growth retardation

decreased embryo size

abnormal head morphology

abnormal anterior head development

microcephaly

acephaly

decreased body size

postnatal growth retardation

Availability

Mouse Genotype

Otx2^tm1Pas/Otx2^tm1Pas

Otx2^tm1Sia/Otx2^tm1Sia

Otx2^tm1Sla/Otx2^tm1Sla

Otx2^tm2.1Imat/Otx2^tm2.1Imat

Otx2^tm2Asim/Otx2^tm2Asim

Otx2^tm3Tlam/Otx2^tm3Tlam

Otx2^tm9Asim/Otx2^tm9Asim

Otx2^tm10Asim/Otx2^tm10Asim

Otx2^tm1Pas/Otx2^tm2Asim

Otx2^tm1Sia/Otx2⁺

Otx2^tm9Asim/Otx2^tm11Asim

Otx2^tm10Asim/Otx2^tm11Asim

Otx2^tm12.1Asim/Otx2^tm11Asim

Otx2^tm1.1Tlam/Otx2^{tm2(cre/ERT2)Tlam} (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23