About   Help   FAQ
Symbol
Name
ID
Npr2
natriuretic peptide receptor 2
MGI:97372
Phenotype annotations related to skeleton
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Frontal bossing
Dolichocephaly
Cone-shaped epiphyses of the phalanges of the hand
Short phalanx of finger
Broad finger
Finger clinodactyly
Arachnodactyly
Broad hallux
Long hallux
Short toe
Broad phalanx
Brachydactyly
Short metatarsal
Broad metatarsal
Radial bowing
Hypoplasia of the radius
Short metacarpal
Broad metacarpals
Flared metaphysis
Bowing of the long bones
Limited elbow extension
Acromesomelia
Epiphyseal dysplasia
Sprengel anomaly
Lower thoracic kyphosis
Thoracolumbar kyphosis
Abnormal form of the vertebral bodies
Beaking of vertebral bodies
Ovoid vertebral bodies
Thoracolumbar interpediculate narrowness
Vertebral wedging
Hyperlordosis
Lumbar hyperlordosis
Kyphosis
Scoliosis
Osteopenia
Joint hyperflexibility
Joint laxity
Joint stiffness
Disease(s) Associated with NPR2
acromesomelic dysplasia, Maroteaux type
Miura type epiphyseal chondrodysplasia

Mouse Phenotypes
skeleton phenotype
abnormal cranium morphology
abnormal basicranium morphology
decreased cranium length
decreased cranium width
abnormal neurocranium morphology
enlarged interparietal bone
small supraoccipital bone
enlarged parietal bone
long lower incisors
long upper incisors
long incisors
malocclusion
abnormal mandibular condyloid process morphology
short maxilla
small nasal bone
domed cranium
abnormal phalanx morphology
short humerus
short radius
short ulna
short femur
increased diameter of femur
long femur
long tibia
short tibia
abnormal long bone morphology
abnormal long bone epiphyseal plate morphology
abnormal long bone epiphyseal plate proliferative zone
abnormal long bone hypertrophic chondrocyte zone
decreased width of hypertrophic chondrocyte zone
decreased long bone epiphyseal plate size
disorganized long bone epiphyseal plate
increased long bone epiphyseal plate size
decreased length of long bones
short scapula
abnormal pelvic girdle bone morphology
abnormal axial skeleton morphology
splayed ribs
kyphosis
abnormal vertebrae morphology
abnormal cervical atlas morphology
short vertebral column
abnormal bone trabecula morphology
abnormal chondrocyte morphology
abnormal skeleton development
chondrodystrophy
abnormal endochondral bone ossification
Availability Mouse Genotype
Npr2cn-2J/Npr2cn-2J *
Npr2cn/Npr2cn !
Npr2pwe/Npr2pwe
Npr2slw/Npr2slw
Npr2tm1Gar/Npr2tm1Gar
Tg(Col11a2-Npr2*)28Keoz/0

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory