Symbol
Name
ID

Enpp1
ectonucleotide pyrophosphatase/phosphodiesterase 1
MGI:97370

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Abnormal calcification of the carpal bones

Hypophosphatemic rickets

Elevated alkaline phosphatase of bone origin

Decreased resting energy expenditure

Diabetes mellitus

Type II diabetes mellitus

Insulin resistance

Edema

Hydrops fetalis

Fever

Hyperphosphaturia

Myocardial calcification

Calcification of the aorta

Abdominal aortic calcification

Coronary artery calcification

Arterial calcification

Carotid artery calcification

Generalized arterial calcification

Medial calcification of large arteries

Medial calcification of medium-sized arteries

Ascites

Hepatic calcification

Pancreatic calcification

Calcification of the auricular cartilage

Adrenal calcification

Ectopic calcification

Cerebral calcification

Periarticular calcification

Disease(s) Associated with ENPP1

arterial calcification of infancy

obesity

ossification of the posterior longitudinal ligament of spine

type 2 diabetes mellitus

Mouse Phenotypes		homeostasis/metabolism phenotype	middle ear effusion	abnormal circulating mineral level	abnormal circulating calcium level	abnormal circulating phosphate level	decreased circulating phosphate level	abnormal calcium ion homeostasis	calcinosis	abnormal mineral level	increased alkaline phosphatase activity
Availability	Mouse Genotype	homeostasis/metabolism phenotype	middle ear effusion	abnormal circulating mineral level	abnormal circulating calcium level	abnormal circulating phosphate level	decreased circulating phosphate level	abnormal calcium ion homeostasis	calcinosis	abnormal mineral level	increased alkaline phosphatase activity
	Enpp1^asj-2J/Enpp1^asj-2J
	Enpp1^asj/Enpp1^asj
	Enpp1^ttw/Enpp1^ttw	*
	Enpp1^asj-2J/Enpp1⁺
	Enpp1^asj/Enpp1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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