About Help FAQ

Symbol
Name
ID

Nkx2-5
NK2 homeobox 5
MGI:97350

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Maternal diabetes	Abnormality of chromosome segregation	Neonatal hyperbilirubinemia	Increased circulating thyroglobulin concentration	Edema	Hypothermia	Calcification of the aorta	Decreased circulating free T3	Decreased circulating free T4 concentration	Decreased circulating T4 concentration	Elevated circulating thyroid-stimulating hormone concentration
Disease(s) Associated with NKX2-5	Maternal diabetes	Abnormality of chromosome segregation	Neonatal hyperbilirubinemia	Increased circulating thyroglobulin concentration	Edema	Hypothermia	Calcification of the aorta	Decreased circulating free T3	Decreased circulating free T4 concentration	Decreased circulating T4 concentration
aortic valve disease 2
congenital nongoitrous hypothyroidism 5
hypoplastic left heart syndrome

Mouse Phenotypes		pericardial edema	pericardial effusion	cyanosis	edema	hydrops fetalis	decreased acetylcholinesterase activity
Availability	Mouse Genotype	pericardial edema	pericardial effusion	cyanosis	edema	hydrops fetalis	decreased acetylcholinesterase activity
	Nkx2-5^tm1.1Burg/Nkx2-5^tm1.1Burg
	Nkx2-5^tm1Siz/Nkx2-5^tm1Siz
	Nkx2-5^tm1Wehi/Nkx2-5^tm1Wehi
	Nkx2-5^tm1.1Hkas/Nkx2-5⁺
	Myl2^tm1(cre)Krc/Myl2⁺ Nkx2-5^tm1Krc/Nkx2-5^tm1Krc (conditional)
	Nkx2-5^tm1Krc/Nkx2-5^tm1Krc Isl1^tm1(cre)Tmj/Isl1⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23