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Symbol
Name
ID

Tlr4
toll-like receptor 4
MGI:96824

Phenotype annotations related to cellular

Darker colors indicate more annotations

Human Phenotypes	Gangrene
Disease(s) Associated with TLR4	Gangrene
temporal arteritis

Mouse Phenotypes

abnormal intestinal goblet cell morphology

abnormal glial cell apoptosis

decreased macrophage apoptosis

decreased neuron apoptosis

decreased hepatocyte apoptosis

cellular necrosis

focal hepatic necrosis

renal tubular necrosis

increased cell death

abnormal enterocyte differentiation

abnormal neuron differentiation

abnormal osteoclast differentiation

abnormal macrophage chemotaxis

impaired neutrophil chemotaxis

decreased B cell proliferation

abnormal enterocyte proliferation

abnormal fibroblast proliferation

abnormal muscle cell glucose uptake

Availability

Mouse Genotype

Tlr4^lps-4Btlr/Tlr4^lps-4Btlr

Tlr4^lps-7Btlr/Tlr4^lps-7Btlr

Tlr4^Lps-8Btlr/Tlr4^Lps-8Btlr

Tlr4^Lps-d/Tlr4^Lps-d

Tlr4^lps-del/Tlr4^lps-del

Tlr4^tm1.1Djh/Tlr4^tm1.1Djh

Tlr4^tm1Aki/Tlr4^tm1Aki

Tlr4^lps-7Btlr/Tlr4⁺

Tlr4^Lps-8Btlr/Tlr4⁺

Tlr4^tm1Djh/Tlr4^tm1Djh
Tg(Vil1-cre)997Gum/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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