|
Symbol Name ID |
Lmna
lamin A MGI:96794 |
| Darker colors indicate more annotations |
| Human Phenotypes | Alopecia of scalp |
Sparse scalp hair |
Abnormal eyebrow morphology |
Absent eyebrow |
Loss of eyelashes |
Absent eyelashes |
Breast aplasia |
Breast carcinoma |
Prominent superficial veins |
Prominent superficial blood vessels |
Telangiectasia of the skin |
Patchy alopecia |
Abnormal hair whorl |
Alopecia |
Alopecia totalis |
Hirsutism |
Generalized hirsutism |
Pili torti |
White forelock |
Premature graying of hair |
Abnormality of the nail |
Dystrophic fingernails |
Dystrophic toenail |
Onychogryposis |
Lack of skin elasticity |
Hyperpigmentation of the skin |
Hypermelanotic macule |
Mottled pigmentation |
Generalized abnormality of skin |
Reduced subcutaneous adipose tissue |
Cyanosis |
Poor wound healing |
Prematurely aged appearance |
Premature skin wrinkling |
Progeroid facial appearance |
Subcutaneous calcification |
Aplasia/Hypoplasia of the skin |
Dermal atrophy |
Thin skin |
Papule |
Skin ulcer |
Xanthomatosis |
Poikiloderma |
Thickened skin |
Acanthosis nigricans |
Hyperkeratosis |
Ichthyosis |
Sclerodactyly |
Scleroderma |
Cutaneous melanoma |
Acral lentiginous melanoma |
Squamous cell carcinoma |
| Disease(s) Associated with LMNA | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Emery-Dreifuss muscular dystrophy | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| familial partial lipodystrophy type 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| mandibuloacral dysplasia type A lipodystrophy | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| progeria | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| restrictive dermopathy 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| Werner syndrome |
| Mouse Phenotypes | absent subcutaneous adipose tissue |
decreased subcutaneous adipose tissue amount |
decreased sebaceous gland number |
sebaceous gland hypoplasia |
decreased eccrine gland number |
abnormal coat/hair pigmentation |
alopecia |
sparse hair |
rough coat |
disheveled coat |
abnormal hair follicle morphology |
decreased hair follicle number |
abnormal hair cycle anagen phase |
abnormal skin morphology |
thin dermal layer |
abnormal epidermal layer morphology |
abnormal epidermis stratum basale morphology |
hyperkeratosis |
orthokeratosis |
abnormal epidermis stratum granulosum morphology |
abnormal keratinocyte morphology |
epidermal hyperplasia |
thick epidermis |
flaky skin |
abnormal epidermal melanocyte morphology |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||
| LmnaDhe/LmnaDhe | ||||||||||||||||||||||||||
| LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor | ||||||||||||||||||||||||||
| Lmnatm1.1Otin/Lmnatm1.1Otin | ||||||||||||||||||||||||||
| Lmnatm2Stw/Lmnatm2Stw | ||||||||||||||||||||||||||
| Lmnatm3Lgf/Lmnatm3Lgf | ||||||||||||||||||||||||||
| Lmnatm3Stw/Lmnatm3Stw | ||||||||||||||||||||||||||
| LmnaDhe/Lmna+ | ||||||||||||||||||||||||||
| Lmnatm1Lgf/Lmna+ | ||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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