Symbol
Name
ID

Krt10
keratin 10
MGI:96685

Phenotype annotations related to integument

Darker colors indicate more annotations

Human Phenotypes	Palmoplantar hyperkeratosis	Palmoplantar keratoderma	Erythroderma	Abnormal blistering of the skin	Hyperkeratosis	Cobblestone-like hyperkeratosis	Generalized hyperkeratosis	Congenital nonbullous ichthyosiform erythroderma
Disease(s) Associated with KRT10
epidermolytic hyperkeratosis 2

Mouse Phenotypes

abnormal sebocyte morphology

abnormal sebocyte differentiation

enlarged sebaceous gland

abnormal sebaceous lipid secretion

increased sebum secretion

greasy coat

ruffled hair

waved hair

abnormal skin morphology

abnormal epidermal layer morphology

abnormal epidermis stratum basale morphology

abnormal epidermis stratum corneum morphology

abnormal stratum corneum lipid matrix formation

hyperkeratosis

abnormal epidermis stratum granulosum morphology

increased keratohyalin granule size

hypergranulosis

abnormal epidermis stratum spinosum morphology

acanthosis

abnormal epidermis suprabasal layer morphology

epidermal hyperplasia

blistering

flaky skin

reddish skin

scaly skin

skin lesions

translucent skin

increased sebocyte proliferation

decreased skin tensile strength

Availability

Mouse Genotype

Krt10^tm1Tmm/Krt10^tm1Tmm

Krt10^tm2Tmm/Krt10^tm2Tmm

Krt10^tm1Tmm/Krt10⁺

Krt10^M1Btlr/?

Krt10^tm1Der/Krt10^tm1Der
Tg(KRT14-cre/PGR)1Der/0 (conditional)

Krt10^tm1Der/Krt10⁺
Tg(KRT14-cre/PGR)1Der/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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