|
Symbol Name ID |
Kras
Kirsten rat sarcoma viral oncogene homolog MGI:96680 |
| * | Aspects of the system are reported to show a normal phenotype. |
| ! | Indicates phenotype varies with strain background. |
| Darker colors indicate more annotations |
| Human Phenotypes | Bruising susceptibility |
Low posterior hairline |
Preauricular skin tag |
Adenoma sebaceum |
Aplasia/Hypoplasia of the eyebrow |
Absent eyebrow |
Abnormal eyelash morphology |
Sparse or absent eyelashes |
Palmoplantar keratoderma |
Deep palmar crease |
Wide intermamillary distance |
Supernumerary nipple |
Breast carcinoma |
Jaundice |
Abnormal hair quantity |
Alopecia |
Sparse hair |
Slow-growing hair |
Brittle hair |
Coarse hair |
Curly hair |
Fine hair |
Dystrophic fingernails |
Redundant skin |
Excessive wrinkled skin |
Hyperextensible skin |
Hyperpigmentation of the skin |
Generalized hyperpigmentation |
Irregular hyperpigmentation |
Multiple cafe-au-lait spots |
Multiple lentigines |
Hyperpigmented streaks |
Hypopigmentation of the skin |
Melanocytic nevus |
Dry skin |
Aplasia/Hypoplasia of the skin |
Aplasia cutis congenita |
Nevus |
Epidermal nevus |
Nevus sebaceous |
Linear nevus sebaceous |
Abnormal dermatoglyphics |
Hyperkeratosis |
Ichthyosis |
Neoplasm of the skin |
Basal cell carcinoma |
| Disease(s) Associated with KRAS | ||||||||||||||||||||||||||||||||||||||||||||||
| breast cancer | ||||||||||||||||||||||||||||||||||||||||||||||
| cardiofaciocutaneous syndrome | ||||||||||||||||||||||||||||||||||||||||||||||
| cardiofaciocutaneous syndrome 2 | ||||||||||||||||||||||||||||||||||||||||||||||
| linear nevus sebaceous syndrome | ||||||||||||||||||||||||||||||||||||||||||||||
| Lynch syndrome | ||||||||||||||||||||||||||||||||||||||||||||||
| Noonan syndrome | ||||||||||||||||||||||||||||||||||||||||||||||
| Noonan syndrome 3 | ||||||||||||||||||||||||||||||||||||||||||||||
| oculoectodermal syndrome | ||||||||||||||||||||||||||||||||||||||||||||||
| pancreatic cancer |
| Mouse Phenotypes | integument phenotype |
abnormal skin sebaceous gland morphology |
enlarged sebaceous gland |
sebaceous gland hyperplasia |
ruffled hair |
increased hair follicle cell proliferation |
epidermal hyperplasia |
thick epidermis |
pallor |
increased skin tumor incidence |
increased skin papilloma incidence |
|
| Availability | Mouse Genotype | |||||||||||
| Krastm1Tyj/Krastm1Tyj | ||||||||||||
| Krastm3Tyj/Krastm3Tyj | ||||||||||||
| Krastm2Tyj/Kras+ | ! | |||||||||||
| Krastm3Tyj/Kras+ | ! | |||||||||||
| Krastm4.1Tyj/Kras+ | ||||||||||||
| Krastm4Tyj/Kras+ Tg(Mx1-cre)1Cgn/0 (conditional) |
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| Krastm4Tyj/Kras+ Meox2tm1(cre)Sor/Meox2+ (conditional) |
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| Krastm4Tyj/Kras+ Tg(KRT5-cre/PGR)1Der/? (conditional) |
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| Krastm4Tyj/Kras+ Krt19tm1(cre/ERT)Ggu/Krt19+ (conditional) |
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| Krastm4Tyj/Kras+ Tg(Krt1-15-cre/PGR*)22Cot/0 (conditional) |
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| Krastm4Tyj/Kras+ Shhtm2(cre/ERT2)Cjt/Shh+ (conditional) |
* | |||||||||||
| Krastm4Tyj/Kras+ Tg(IVL-cre/ERT2)1Blpn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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