Symbol
Name
ID

Kras
Kirsten rat sarcoma viral oncogene homolog
MGI:96680

Phenotype annotations related to embryo

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Thickened nuchal skin fold	Polyhydramnios
Disease(s) Associated with KRAS	Thickened nuchal skin fold	Polyhydramnios
Noonan syndrome
Noonan syndrome 3
oculoectodermal syndrome

Mouse Phenotypes

embryo phenotype

abnormal placental labyrinth vasculature morphology

absent vitelline blood vessels

increased embryonic tissue cell apoptosis

embryonic growth arrest

embryonic growth retardation

decreased embryo size

abnormal embryonic neuroepithelium morphology

abnormal placenta labyrinth morphology

pale yolk sac

abnormal embryonic erythropoiesis

Availability

Mouse Genotype

Kras^tm1Mok/Kras^tm1Mok

Kras^tm1Tyj/Kras^tm1Tyj

Kras^tm4.1Tyj/Kras⁺

Kras^tm4Tyj/Kras⁺
Tg(Prm-cre)58Og/0 (conditional)

Kras^tm4Tyj/Kras⁺
Tg(Tek-cre)12Flv/0 (conditional)

Kras^tm4Tyj/Kras⁺
Meox2^tm1(cre)Sor/Meox2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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