Symbol
Name
ID

Htr2c
5-hydroxytryptamine (serotonin) receptor 2C
MGI:96281

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Negativism
Disease(s) Associated with HTR2C	Negativism
schizophrenia

Mouse Phenotypes

behavior/neurological phenotype

increased susceptibility to pharmacologically induced seizures

enhanced behavioral response to xenobiotic

impaired behavioral response to xenobiotic

impaired passive avoidance behavior

abnormal response to new environment

abnormal spatial learning

decreased food intake

increased food intake

polyphagia

increased coping response

increased grooming behavior

abnormal pilomotor reflex

impaired coordination

decreased grip strength

hunched posture

decreased locomotor activity

hyperactivity

seizures

tonic seizures

tonic-clonic seizures

sporadic seizures

Availability

Mouse Genotype

Htr2c^tm1.1Eme/Htr2c⁺

Htr2c^tm1.1Eme/Y

Htr2c^tm1Arte/Y

Htr2c^tm1Jke/Y

Htr2c^tm1Jul/Y

Htr2c^tm1Knk/Y

Htr2c^tm2Jke/Htr2c^tm2Jke
Tg(Pomc1-cre)16Lowl/0 (conditional)

Htr2c^tm2Jke/Htr2c^tm2Jke
Tg(Pomc-cre/ERT2)#Jke/0 (conditional)

Htr2c^tm1Jke/Y
Tg(Pomc1-cre)16Lowl/0 (conditional)

Htr2c^tm2Jke/Y
Tg(Zp3-cre)93Knw/0 (conditional)

Htr2c^tm2Jke/Y
Tg(Pomc1-cre)16Lowl/0 (conditional)

Htr2c^tm2Jke/Y
Tg(Pomc-cre/ERT2)#Jke/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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