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Symbol
Name
ID

Hr
lysine demethylase and nuclear receptor corepressor
MGI:96223

Phenotype annotations related to integument

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Absent eyebrow	Absent eyelashes	Absent axillary hair	Absent pubic hair	Alopecia universalis	Sparse hair	Generalized papillary lesions
Disease(s) Associated with HR	Absent eyebrow	Absent eyelashes	Absent axillary hair	Absent pubic hair	Alopecia universalis	Sparse hair	Generalized papillary lesions
alopecia universalis
atrichia with papular lesions

Mouse Phenotypes

integument phenotype

abnormal keratinocyte differentiation

abnormal mammary gland morphology

abnormal nipple development

absent mammary gland

decreased nipple number

abnormal sebaceous gland morphology

decreased sebocyte cell number

abnormal Meibomian gland morphology

Meibomian gland cyst

abnormal Meibomian gland acinus morphology

Meibomian gland atrophy

small sebaceous gland

sebaceous gland atrophy

abnormal lactation

dermal cyst

epidermal cyst

abnormal coat/ hair morphology

abnormal coat appearance

abnormal hair growth

alopecia

hairless

loss of eyelid cilia

progressive hair loss

short hair

sparse hair

abnormal hair shaft morphology

thin hypodermis

deformed nails

long toenails

abnormal hair follicle morphology

abnormal hair follicle dermal papilla morphology

absent hair follicle dermal papilla

abnormal hair follicle infundibulum morphology

dilated hair follicle infundibulum

abnormal hair follicle inner root sheath morphology

abnormal hair follicle outer root sheath morphology

abnormal piliary canal morphology

dilated piliary canal

dilated hair follicle

distended hair follicles

hair follicle degeneration

abnormal vibrissa follicle morphology

abnormal vibrissa morphology

abnormal vibrissa number

absent vibrissae

curly vibrissae

loss of vibrissae

short vibrissae

wavy vibrissae

abnormal skin adnexa physiology

abnormal hair cycle

abnormal skin morphology

abnormal dermal layer morphology

abnormal dermis reticular layer morphology

thick dermal layer

abnormal epidermal layer morphology

abnormal epidermis stratum corneum morphology

hyperkeratosis

abnormal epidermis stratum granulosum morphology

epidermis stratum granulosum hyperplasia

hypergranulosis

acanthosis

epidermal hyperplasia

thick epidermis

abnormal skin appearance

flaky skin

loose skin

shiny skin

skin lesions

skin ridges

translucent skin

wrinkled skin

skin hyperplasia

abnormal skin condition

thick skin

thin skin

Availability

Mouse Genotype

Hr^ba/Hr^ba

Hr^bldy/Hr^bldy

Hr^em1(IMPC)H/Hr^em1(IMPC)H

Hr^Hp/Hr^Hp

Hr^hr+/Hr^hr+

*

Hr^hr-2Pas/Hr^hr-2Pas

Hr^hr/Hr^hr

Hr^m1Btlr/Hr^m1Btlr

Hr^m1Enu/Hr^m1Enu

Hr^m2Btlr/Hr^m2Btlr

Hr^M3Btlr/Hr^M3Btlr

Hr^m4Btlr/Hr^m4Btlr

Hr^m5Btlr/Hr^m5Btlr

Hr^m6Btlr/Hr^m6Btlr

Hr^N/Hr^N

Hr^rh-8J/Hr^rh-8J

Hr^rh-10J/Hr^rh-10J

Hr^rh-bmh/Hr^rh-bmh

Hr^rh-Chr/Hr^rh-Chr

Hr^rh-R/Hr^rh-R

Hr^rh-Y/Hr^rh-Y

Hr^rh/Hr^rh

Hr^rhsl/Hr^rhsl

Hr^Tg5053Mm/Hr^Tg5053Mm

Hr^tm1Cct/Hr^tm1Cct

Hr^USP/Hr^USP

Hr^Hp/Hr⁺

Hr^hr/Hr^hr-3J

Hr^hr/Hr^rh-2J

Hr^N/Hr⁺

Hr^N/Hr^hr

Hr^rh-7J/Hr^rh

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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