Symbol
Name
ID

Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
MGI:95821

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Feeding difficulties	Depression	Atypical behavior	Negativism	Personality changes
Disease(s) Associated with GRIN2B	Feeding difficulties	Depression	Atypical behavior	Negativism	Personality changes
autosomal dominant intellectual developmental disorder 6
developmental and epileptic encephalopathy 27
Huntington's disease
schizophrenia

Mouse Phenotypes

behavior/neurological phenotype

abnormal learning/memory/conditioning

abnormal associative learning

enhanced contextual conditioning behavior

abnormal cued conditioning behavior

enhanced cued conditioning behavior

abnormal discrimination learning

abnormal object recognition memory

enhanced long-term object recognition memory

abnormal spatial learning

abnormal spatial reference memory

abnormal spatial working memory

abnormal temporal memory

absent gastric milk in neonates

abnormal suckling behavior

absent suckling reflex

increased coping response

decreased anxiety-related response

increased thigmotaxis

fast extinction of fear memory

increased startle reflex

abnormal motor coordination/balance

impaired coordination

impaired swimming

decreased locomotor activity

increased locomotor activity

hyperactivity

social withdrawal

Availability

Mouse Genotype

Grin2b^em1Weya/Grin2b^em1Weya

Grin2b^tm1.1Jwhe/Grin2b^tm1.1Jwhe

Grin2b^tm1Mim/Grin2b^tm1Mim

Grin2b^tm1Tya/Grin2b^tm1Tya

Grin2b^{tm1e.1(KOMP)Wtsi}/Grin2b⁺

Grin2b^tm1Mim/Grin2b⁺

Grin2b^tm1Rsp/Grin2b⁺

Tg(Camk2a-Grin2b)1Jzt/?

Grin2b^tm1.1Jlbr/Grin2b^tm1.1Jlbr
Tg(Camk2a-cre)T29-1Stl/0 (conditional)

Grin2b^tm1.1Jlbr/Grin2b^tm1.1Jlbr
Neurod6^tm1(cre)Kan/Neurod6⁺ (conditional)

Grin2b^tm1Mony/Grin2b^tm1Mony
Tg(Camk2a-cre)1Gsc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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