Symbol
Name
ID

Gnas
GNAS complex locus
MGI:95777

Phenotype annotations related to craniofacial

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Thickened calvaria	Round face	Full cheeks	Delayed eruption of teeth	Enamel hypoplasia	Depressed nasal bridge	Conjunctivitis
Disease(s) Associated with GNAS	Thickened calvaria	Round face	Full cheeks	Delayed eruption of teeth	Enamel hypoplasia	Depressed nasal bridge	Conjunctivitis
ACTH-independent macronodular adrenal hyperplasia 1
Albright's hereditary osteodystrophy
pseudohypoparathyroidism
pseudohypoparathyroidism type IB
pseudopseudohypoparathyroidism

Mouse Phenotypes

craniofacial phenotype

abnormal craniofacial morphology

abnormal craniofacial bone morphology

abnormal hyoid bone morphology

abnormal hyoid bone body morphology

abnormal incisor morphology

abnormal mandible morphology

absent mandibular angle

absent mandibular condyloid process

absent mandibular coronoid process

mandible hypoplasia

short mandible

abnormal maxilla morphology

abnormal premaxilla morphology

maxilla hypoplasia

short maxilla

domed cranium

palate bone hypoplasia

absent nasal capsule

palatal shelves fail to meet at midline

round face

complete cleft palate

abnormal tongue morphology

protruding tongue

abnormal nasal septum cartilage morphology

short snout

abnormal outer ear morphology

Availability

Mouse Genotype

Gnas^tm1Lsw/Gnas⁺

Gnas^tm3Lsw/Gnas^tm3Lsw
Tg(Col2a1-cre)1Rsjo/0 (conditional)

Gnas^tm5.1Lsw/Gnas^tm5.1Lsw
H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Gnas^tm5.1Lsw/Gnas^tm5.1Lsw
Tg(Nes-cre)1Atp/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23